Background: Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, is linked to a range of extraintestinal symptoms, with skin issues being both common and important. These skin manifestations can indicate how active the disease is and often require coordinated care from both dermatologists and gastroenterologists.

Objective: The goal of this study was to explore the different skin manifestations associated with IBD, assess how often they occur, their clinical characteristics, how they respond to treatment, and their relationship with disease activity based on existing literature and compiled data.

Methods: To achieve this, we conducted a thorough review of peer-reviewed articles and clinical studies focusing on the mucocutaneous aspects of IBD. We organized the data to categorize skin conditions into specific, reactive, associated, or treatment-related categories. We also analyzed the clinical responses to various therapies, presenting our findings through tables and graphs for clarity.

Result: Our findings revealed that reactive skin conditions, especially erythema nodosum and pyoderma gangrenosum, were the most common, with erythema nodosum often linked to active intestinal disease. We also noted an increase in treatment-related skin issues, such as biologic-induced eczema and paradoxical psoriasis, as biologic therapies have become more prevalent. Biologics showed great effectiveness in treating stubborn lesions, particularly pyoderma gangrenosum. Skin involvement was notably more frequent during active IBD phases.

Conclusion: In conclusion, skin manifestations in IBD are varied and often mirror the overall disease activity. Recognizing these signs early and managing them with a multidisciplinary approach is essential for achieving the best outcomes. Targeted treatments, especially biologics, are crucial for addressing severe or resistant skin lesions.