Background:Myiasis is defined as invasion of tissues by Diptera flies. The condition is endemic in the forested areas of Mexico, Central and South America. Main observations:A 61-year-old woman presented with two boil-like inflammatory and painful lesions on her back. She had been travelling in Central America. Biopsies revealed a myiasis with mature third instar larvae of Dermatobia hominis, a diptera fly endemic in this region. Complete surgical excision and systemic antibiosis led to a delayed but complete healing.Conclusion:We presented a patient with a double infestation by Dermatobia hominis. Dermatologists should be aware of this disease, which has become increasingly common in travellers and is seen now also in unusual regions, other than Central and South America.